Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.3
USERS' SCORE
Good
Based on 7 Reviews
8.4
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Mood Probiotic BlendLactobacillus acidophilusLactobacillus plantarumLactobacillus helveticus R0052Lactobacillus paracaseiLactobacillus caseiLactobacillus brevisLactobacillus rhamnosusLactobacillus bulgaricusLactobacillus gasseriLactobacillus salivariusTotal Lacto Cultures (45 Billion CFU)Bifidobacterium lactisBifidobacterium longum R0175Bifidobacterium bifidumBifidobacterium breveBifidobacterium infantisBifidobacterium longumTotal Bifido Cultures (5 Billion CFU)
200 mg
+
Total Probiotic Cultures
50 Billion CFU¹
Stress Support BlendOrganic Ashwagandha (root), Blueberry (fruit)
350 mg
+
Organic Prebiotic Fiber BlendOrganic Potato [Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
675 mg
+
Top Medical Research Studies
9
We examined the effect of lactic acid bacteria, particularly Lactobacillus gasseri, on the harmful yeast Candida albicans. Our study showed that the metabolites from L. gasseri effectively inhibit the yeast's ability to grow and form biofilms, crucial for its pathogenicity. The research also indicated that these beneficial bacteria can keep C. albicans in a less harmful state by downregulating important genes responsible for its virulence. Overall, L. gasseri appears to be a promising option in the fight against vaginal yeast infections.
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9.5
We investigated whether Lactobacillus salivarius MG242 can help fight vulvovaginal candidiasis (VVC), a common yeast infection caused by Candida albicans. According to our findings, this particular strain successfully inhibited the growth of C. albicans by an impressive 99.99%.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
Read More
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Read More
Most Useful Reviews
8
Effective for yeast infection
19 people found this helpful
The effect is very good. I often experience a recurrence of yeast infection, particularly when I exercise in hot, humid conditions, and symptoms such as itching worsen before menstruation. This product, featuring 50 billion lactobacillus strains crafted by doctors, is a bit pricey, but I'm very satisfied with it. I take it first thing in the morning while fasting and would recommend it due to its effectiveness. While Garden of Life products are costly, they prioritise quality and the nutritional composition of their strains. One tablet a day lasts two months, making it affordable when considering the health benefits. I believe 80% of my immunity comes from gut health, and consistent intake is essential for maximising its benefits. The inclusion of prebiotics enhances the absorption of lactic acid bacteria, which is advantageous.
Read More
9
Relieves gynecological infections
1 people found this helpful
A wonderful product, especially recommended after antibiotic treatment. It effectively eases burning sensations and relieves gynecological infections. Taking two pills on an empty stomach has proven very useful.
Read More
9
Effective for infections
Excellent for those suffering from vaginal infections, it also aids in relieving urinary tract infections.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.3
- All Researches
9.5
We investigated how Lactobacillus rhamnosus Lcr35, contained in the GYNOPHILUS product, can combat yeast infections like Candida. This study showed that the product’s formulation, enhanced by sodium thiosulfate, improves its ability to kill yeast cells.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Read More
9.5
We investigated whether Lactobacillus salivarius MG242 can help fight vulvovaginal candidiasis (VVC), a common yeast infection caused by Candida albicans. According to our findings, this particular strain successfully inhibited the growth of C. albicans by an impressive 99.99%.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
This significant reduction in yeast growth suggests that L. salivarius MG242 holds promise as a potential probiotic treatment for VVC. Moreover, we found ways to enhance its stability and shelf-life, making it a candidate for future formulations.
Read More
9
We examined how a combination of ultra-low-dose estriol and lactobacilli affects vaginal health in postmenopausal women dealing with severe atrophic vaginitis while on aromatase inhibitors. Over 28 days, 16 breast cancer survivors used Gynoflor®, improving their vaginal flora. Remarkably, the lactobacillary grades increased significantly, alongside reductions in inflammatory markers like leukocytes and parabasal cells.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Read More
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Read More
9
We examined the effectiveness of various Lactobacillus strains, particularly Lactobacillus rhamnosus, against yeast infections caused by Candida. Through our analysis, we found that live probiotic cells and their cell-free supernatants showed strong anticandidal activity.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8
Effective for yeast infection
19 people found this helpful
The effect is very good. I often experience a recurrence of yeast infection, particularly when I exercise in hot, humid conditions, and symptoms such as itching worsen before menstruation. This product, featuring 50 billion lactobacillus strains crafted by doctors, is a bit pricey, but I'm very satisfied with it. I take it first thing in the morning while fasting and would recommend it due to its effectiveness. While Garden of Life products are costly, they prioritise quality and the nutritional composition of their strains. One tablet a day lasts two months, making it affordable when considering the health benefits. I believe 80% of my immunity comes from gut health, and consistent intake is essential for maximising its benefits. The inclusion of prebiotics enhances the absorption of lactic acid bacteria, which is advantageous.
Read More
9
Relieves gynecological infections
1 people found this helpful
A wonderful product, especially recommended after antibiotic treatment. It effectively eases burning sensations and relieves gynecological infections. Taking two pills on an empty stomach has proven very useful.
Read More
9
Effective for infections
Excellent for those suffering from vaginal infections, it also aids in relieving urinary tract infections.
Read More
9
Supports women's health
Excellent yeasts for women's health; they greatly benefit the digestive and immune systems, as well as improve mood.
Read More
9
Saved from infections
1 people found this helpful
The best company I have ever used for probiotics, particularly the type designated for women, which has significantly reduced my infections.
Read More
Frequently Asked Questions
9
Relieves gynecological infections
1 people found this helpful
A wonderful product, especially recommended after antibiotic treatment. It effectively eases burning sensations and relieves gynecological infections. Taking two pills on an empty stomach has proven very useful.
8
Effective for yeast infection
19 people found this helpful
The effect is very good. I often experience a recurrence of yeast infection, particularly when I exercise in hot, humid conditions, and symptoms such as itching worsen before menstruation. This product, featuring 50 billion lactobacillus strains crafted by doctors, is a bit pricey, but I'm very satisfied with it. I take it first thing in the morning while fasting and would recommend it due to its effectiveness. While Garden of Life products are costly, they prioritise quality and the nutritional composition of their strains. One tablet a day lasts two months, making it affordable when considering the health benefits. I believe 80% of my immunity comes from gut health, and consistent intake is essential for maximising its benefits. The inclusion of prebiotics enhances the absorption of lactic acid bacteria, which is advantageous.
9
Supports women's health
Excellent yeasts for women's health; they greatly benefit the digestive and immune systems, as well as improve mood.
7.5
Improved digestion noted
5 people found this helpful
The quality is excellent, and I highly recommend it, although I had to stop taking it while breastfeeding due to safety concerns for my baby. My experience was positive, as it helped me sleep comfortably and alleviated my insomnia. It also improved my digestive issues post-childbirth, and proved beneficial for gynecological infections. Remarkably, I noticed a lift in my mood, which my husband also recognised. Once I stop breastfeeding, I plan to use it regularly. If this review helps, please like it!
9
Effective for infections
Excellent for those suffering from vaginal infections, it also aids in relieving urinary tract infections.
7
We examined a series of studies focusing on the effects of Lactobacillus probiotics against Candida species, which cause yeast infections affecting many adult women. Reviewing 15 articles from 2015 to 2020, we noticed that particular strains like L. acidophilus can inhibit Candida growth.
Extended use of these probiotics seems to improve treatment outcomes, especially when combined with traditional medications. Our findings suggest that the combination of the right Lactobacillus strain and duration of use plays a crucial role in tackling these stubborn infections.
Extended use of these probiotics seems to improve treatment outcomes, especially when combined with traditional medications. Our findings suggest that the combination of the right Lactobacillus strain and duration of use plays a crucial role in tackling these stubborn infections.
8
We examined the impacts of combining standard azole therapy with a local probiotic treatment to combat recurrent yeast infections. Involving 436 women, we divided participants into two groups: one receiving standard azole treatment alone and the other receiving the same treatment along with Lactobacillus acidophilus probiotics.
The results were telling. While over 79% of women in the azole-only group experienced lingering symptoms, those in the probiotic group saw this drop to just 31%. Additionally, microbiological success rates improved significantly, indicating that probiotics enhance the effectiveness of conventional treatments for vaginal Candida infections.
The results were telling. While over 79% of women in the azole-only group experienced lingering symptoms, those in the probiotic group saw this drop to just 31%. Additionally, microbiological success rates improved significantly, indicating that probiotics enhance the effectiveness of conventional treatments for vaginal Candida infections.
8
Lactobacilli may reduce Candida virulence
We examined how cell-free supernatants from lactobacilli, specifically L. acidophilus, L. plantarum, L. rhamnosus, and L. reuteri, affect the virulence traits of Candida parapsilosis in the context of vulvovaginal candidiasis. Our findings indicated that these lactobacilli can reduce the growth and harmful effects of C. parapsilosis, helping to enhance the vaginal lining's resistance to infection. This suggests that incorporating these lactobacilli could be beneficial in preventing yeast infections caused by non-albicans species like C. parapsilosis, although more research is needed to fully understand their effectiveness.
9
We examined the effectiveness of various Lactobacillus strains, particularly Lactobacillus rhamnosus, against yeast infections caused by Candida. Through our analysis, we found that live probiotic cells and their cell-free supernatants showed strong anticandidal activity.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
References
- Pimentel MMNSC, de Carvalho Alves J, Pinheiro LHS, Roselino MN. Potential Action of Probiotics Against Fungi of the Genus : A Bibliographic Review. Recent Pat Biotechnol. 2023;17:198. doi:10.2174/1872208317666221027093644
- Spaggiari L, Sala A, Ardizzoni A, De Seta F, Singh DK, et al. Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System . Microbiol Spectr. 2022;10:e0269621. doi:10.1128/spectrum.02696-21
- Er S, İstanbullu Tosun A, Arık G, Kıvanç M. Anticandidal activities of lactic acid bacteria isolated from the vagina. Turk J Med Sci. 2019;49:375. doi:10.3906/sag-1709-143
- Mezzasalma V, Manfrini E, Ferri E, Boccarusso M, Di Gennaro P, et al. Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. Arch Gynecol Obstet. 2017;295:163. doi:10.1007/s00404-016-4235-2
- Matsubara VH, Wang Y, Bandara HMHN, Mayer MPA, Samaranayake LP. Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation. Appl Microbiol Biotechnol. 2016;100:6415. doi:10.1007/s00253-016-7527-3
- Donders G, Bellen G, Neven P, Grob P, Prasauskas V, et al. Effect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors. Eur J Clin Microbiol Infect Dis. 2015;34:2023. doi:10.1007/s10096-015-2447-1
- Vilela SF, Barbosa JO, Rossoni RD, Santos JD, Prata MC, et al. Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella. Virulence. 2015;6:29. doi:10.4161/21505594.2014.981486
- Kovachev SM, Vatcheva-Dobrevska RS. Local Probiotic Therapy for Vaginal Candida albicans Infections. Probiotics Antimicrob Proteins. 2015;7:38. doi:10.1007/s12602-014-9176-0
- Ishikawa KH, Mayer MP, Miyazima TY, Matsubara VH, Silva EG, et al. A multispecies probiotic reduces oral Candida colonization in denture wearers. J Prosthodont. 2015;24:194. doi:10.1111/jopr.12198
- Chantanawilas P, Pahumunto N, Thananimit S, Teanpaisan R. Anticandidal Activity of Various Probiotic Lactobacillus Strains and Their Efficacy Enhanced by Prebiotic Supplementation. Curr Microbiol. 2024;81:271. doi:10.1007/s00284-024-03800-y
- Dausset C, Bornes S, Miquel S, Kondjoyan N, Angenieux M, et al. Identification of sulfur components enhancing the anti-Candida effect of Lactobacillus rhamnosus Lcr35. Sci Rep. 2020;10:17074. doi:10.1038/s41598-020-74027-7
- Kumherová M, Veselá K, Kosová M, Mašata J, Horáčková Š, et al. Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections. Probiotics Antimicrob Proteins. 2021;13:163. doi:10.1007/s12602-020-09675-2
- Poupet C, Saraoui T, Veisseire P, Bonnet M, Dausset C, et al. Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights. PLoS One. 2019;14:e0216184. doi:10.1371/journal.pone.0216184
- Lee X, Vergara C, Lozano CP. Severity of Candida-associated denture stomatitis is improved in institutionalized elders who consume Lactobacillus rhamnosus SP1. Aust Dent J. 2019;64:229. doi:10.1111/adj.12692
- De Gregorio PR, Silva JA, Marchesi A, Nader-Macías MEF. Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model. FEMS Yeast Res. 2019;19. doi:10.1093/femsyr/foz008
- Leão MVP, Tavares TAA, Gonçalves E Silva CR, Dos Santos SSF, Junqueira JC, et al. Lactobacillus rhamnosus intake can prevent the development of Candidiasis. Clin Oral Investig. 2018;22:2511. doi:10.1007/s00784-018-2347-8
- Rossoni RD, Dos Santos Velloso M, Figueiredo LMA, Martins CP, Jorge AOC, et al. Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis. Folia Microbiol (Praha). 2018;63:307. doi:10.1007/s12223-017-0569-9
- Tan Y, Leonhard M, Moser D, Ma S, Schneider-Stickler B. Inhibitory effect of probiotic lactobacilli supernatants on single and mixed non-albicans Candida species biofilm. Arch Oral Biol. 2018;85:40. doi:10.1016/j.archoralbio.2017.10.002
- Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, et al. Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One. 2017;12:e0184438. doi:10.1371/journal.pone.0184438
- de Oliveira FE, Rossoni RD, de Barros PP, Begnini BE, Junqueira JC, et al. Immunomodulatory effects and anti-Candida activity of lactobacilli in macrophages and in invertebrate model of Galleria mellonella. Microb Pathog. 2017;110:603. doi:10.1016/j.micpath.2017.08.006
- Das S, Konwar BK. Inhibiting pathogenicity of vaginal Candida albicans by lactic acid bacteria and MS analysis of their extracellular compounds. APMIS. 2024;132:161. doi:10.1111/apm.13365
- Giordani B, Naldi M, Croatti V, Parolin C, Erdoğan Ü, et al. Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms. Microb Cell Fact. 2023;22:45. doi:10.1186/s12934-023-02053-x
- Rodríguez-Arias RJ, Guachi-Álvarez BO, Montalvo-Vivero DE, Machado A. Lactobacilli displacement and Candida albicans inhibition on initial adhesion assays: a probiotic analysis. BMC Res Notes. 2022;15:239. doi:10.1186/s13104-022-06114-z
- Matsuda Y, Cho O, Sugita T, Ogishima D, Takeda S. Culture Supernatants of Lactobacillus gasseri and L. crispatus Inhibit Candida albicans Biofilm Formation and Adhesion to HeLa Cells. Mycopathologia. 2018;183:691. doi:10.1007/s11046-018-0259-4
- Calonghi N, Parolin C, Sartor G, Verardi L, Giordani B, et al. Interaction of vaginal Lactobacillus strains with HeLa cells plasma membrane. Benef Microbes. 2017;8:625. doi:10.3920/BM2016.0212
- Terayama Y, Matsuura T, Uchida M, Narama I, Ozaki K. Probiotic (yogurt) containing Lactobacillus gasseri OLL2716 is effective for preventing Candida albicans-induced mucosal inflammation and proliferation in the forestomach of diabetic rats. Histol Histopathol. 2016;31:689. doi:10.14670/HH-11-710
- Parolin C, Marangoni A, Laghi L, Foschi C, Ñahui Palomino RA, et al. Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity. PLoS One. 2015;10:e0131220. doi:10.1371/journal.pone.0131220
- Mastromarino P, Brigidi P, Macchia S, Maggi L, Pirovano F, et al. Characterization and selection of vaginal Lactobacillus strains for the preparation of vaginal tablets. J Appl Microbiol. 2002;93:884.
- Kang CH, Han SH, Kim Y, Paek NS, So JS. In Vitro Probiotic Properties of Lactobacillus salivarius MG242 Isolated from Human Vagina. Probiotics Antimicrob Proteins. 2018;10:343. doi:10.1007/s12602-017-9323-5
- Kumar S, Singhi S, Chakrabarti A, Bansal A, Jayashree M. Probiotic use and prevalence of candidemia and candiduria in a PICU. Pediatr Crit Care Med. 2013;14:e409. doi:10.1097/PCC.0b013e31829f5d88
- Kumar S, Bansal A, Chakrabarti A, Singhi S. Evaluation of efficacy of probiotics in prevention of candida colonization in a PICU-a randomized controlled trial. Crit Care Med. 2013;41:565. doi:10.1097/CCM.0b013e31826a409c
- Li D, Li Q, Liu C, Lin M, Li X, et al. Efficacy and safety of probiotics in the treatment of Candida-associated stomatitis. Mycoses. 2014;57:141. doi:10.1111/myc.12116
